IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway.
Identifieur interne : 000A31 ( Main/Exploration ); précédent : 000A30; suivant : 000A32IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway.
Auteurs : Chutima Roomruangwong [Thaïlande] ; Buranee Kanchanatawan [Thaïlande] ; Sunee Sirivichayakul [Thaïlande] ; George Anderson [Royaume-Uni] ; André F. Carvalho [Brésil] ; Sebastien Duleu [France] ; Michel Geffard [France] ; Michael Maes [Thaïlande]Source :
- Metabolic brain disease [ 1573-7365 ] ; 2017.
Abstract
Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio-somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts were assayed in pregnant women with (n = 24) and without prenatal depression (n = 25) as well as in 24 non-pregnant women. Associations of IgM/IgA responses to Gram-negative gut commensal bacteria (leaky gut index) and IgA/IgM responses to tryptophan catabolites (TRYCATs) were analyzed. IgM responses to OSEs, but not NO-adducts, were significantly reduced at the end of term. There were no significant associations between IgM responses to OSEs and perinatal depression, whilst IgM responses to NO-adducts, especially NO-cysteinyl, were significantly associated with a lifetime major depression. IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. IgM responses to NO-adducts and OSEs, especially malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely associated with TRYCAT pathway activity, whilst a lifetime depression and Pseudomonas putida were positively associated. The attenuation of natural IgM-mediated responses to OSEs at the end of term may indicate lowered activity of this part of the compensatory (anti-)inflammatory reflex system and may be partly explained by lowered bacterial translocation. Increased IgM responses to NO-cysteinyl is a biomarker of lifetime depression and may be induced by bacterial translocation. Natural IgM-mediated autoimmune responses, increased nitrosylation and higher CRP levels may have negative regulatory effects on the TRYCAT pathway.
DOI: 10.1007/s11011-017-0040-2
PubMed: 28600633
Affiliations:
- Brésil, France, Royaume-Uni, Thaïlande
- Angleterre, Aquitaine, Aquitaine-Limousin-Poitou-Charentes, Ceará, Grand Londres
- Bordeaux, Londres, Talence
- Université fédérale du Ceará
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000315
- to stream PubMed, to step Curation: 000313
- to stream PubMed, to step Checkpoint: 000313
- to stream Ncbi, to step Merge: 004959
- to stream Ncbi, to step Curation: 004959
- to stream Ncbi, to step Checkpoint: 004959
- to stream Main, to step Merge: 000A26
- to stream Main, to step Curation: 000A31
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway.</title><author><name sortKey="Roomruangwong, Chutima" sort="Roomruangwong, Chutima" uniqKey="Roomruangwong C" first="Chutima" last="Roomruangwong">Chutima Roomruangwong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Kanchanatawan, Buranee" sort="Kanchanatawan, Buranee" uniqKey="Kanchanatawan B" first="Buranee" last="Kanchanatawan">Buranee Kanchanatawan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Sirivichayakul, Sunee" sort="Sirivichayakul, Sunee" uniqKey="Sirivichayakul S" first="Sunee" last="Sirivichayakul">Sunee Sirivichayakul</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, George" sort="Anderson, George" uniqKey="Anderson G" first="George" last="Anderson">George Anderson</name><affiliation wicri:level="3"><nlm:affiliation>CRC Scotland & London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Scotland & London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Carvalho, Andre F" sort="Carvalho, Andre F" uniqKey="Carvalho A" first="André F" last="Carvalho">André F. Carvalho</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE</wicri:regionArea><placeName><region type="state">Ceará</region></placeName><orgName type="university">Université fédérale du Ceará</orgName></affiliation></author><author><name sortKey="Duleu, Sebastien" sort="Duleu, Sebastien" uniqKey="Duleu S" first="Sebastien" last="Duleu">Sebastien Duleu</name><affiliation wicri:level="3"><nlm:affiliation>Research Department, IDRPHT, Talence, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Research Department, IDRPHT, Talence</wicri:regionArea><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement><settlement type="city" wicri:auto="agglo">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name><affiliation wicri:level="3"><nlm:affiliation>Research Department, IDRPHT, Talence, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Research Department, IDRPHT, Talence</wicri:regionArea><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement><settlement type="city" wicri:auto="agglo">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michael" last="Maes">Michael Maes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. dr.michaelmaes@hotmail.com.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28600633</idno><idno type="pmid">28600633</idno><idno type="doi">10.1007/s11011-017-0040-2</idno><idno type="wicri:Area/PubMed/Corpus">000315</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000315</idno><idno type="wicri:Area/PubMed/Curation">000313</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000313</idno><idno type="wicri:Area/PubMed/Checkpoint">000313</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000313</idno><idno type="wicri:Area/Ncbi/Merge">004959</idno><idno type="wicri:Area/Ncbi/Curation">004959</idno><idno type="wicri:Area/Ncbi/Checkpoint">004959</idno><idno type="wicri:Area/Main/Merge">000A26</idno><idno type="wicri:Area/Main/Curation">000A31</idno><idno type="wicri:Area/Main/Exploration">000A31</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway.</title><author><name sortKey="Roomruangwong, Chutima" sort="Roomruangwong, Chutima" uniqKey="Roomruangwong C" first="Chutima" last="Roomruangwong">Chutima Roomruangwong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Kanchanatawan, Buranee" sort="Kanchanatawan, Buranee" uniqKey="Kanchanatawan B" first="Buranee" last="Kanchanatawan">Buranee Kanchanatawan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Sirivichayakul, Sunee" sort="Sirivichayakul, Sunee" uniqKey="Sirivichayakul S" first="Sunee" last="Sirivichayakul">Sunee Sirivichayakul</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, George" sort="Anderson, George" uniqKey="Anderson G" first="George" last="Anderson">George Anderson</name><affiliation wicri:level="3"><nlm:affiliation>CRC Scotland & London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>CRC Scotland & London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Carvalho, Andre F" sort="Carvalho, Andre F" uniqKey="Carvalho A" first="André F" last="Carvalho">André F. Carvalho</name><affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Clinical Medicine and Translational Psychiatry Research Group, Faculty of Medicine, Federal University of Ceará, Fortaleza, CE</wicri:regionArea><placeName><region type="state">Ceará</region></placeName><orgName type="university">Université fédérale du Ceará</orgName></affiliation></author><author><name sortKey="Duleu, Sebastien" sort="Duleu, Sebastien" uniqKey="Duleu S" first="Sebastien" last="Duleu">Sebastien Duleu</name><affiliation wicri:level="3"><nlm:affiliation>Research Department, IDRPHT, Talence, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Research Department, IDRPHT, Talence</wicri:regionArea><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement><settlement type="city" wicri:auto="agglo">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name><affiliation wicri:level="3"><nlm:affiliation>Research Department, IDRPHT, Talence, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Research Department, IDRPHT, Talence</wicri:regionArea><placeName><region type="region" nuts="2">Aquitaine-Limousin-Poitou-Charentes</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement><settlement type="city" wicri:auto="agglo">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michael" last="Maes">Michael Maes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. dr.michaelmaes@hotmail.com.</nlm:affiliation><country xml:lang="fr">Thaïlande</country><wicri:regionArea>Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok</wicri:regionArea><wicri:noRegion>Bangkok</wicri:noRegion></affiliation></author></analytic><series><title level="j">Metabolic brain disease</title><idno type="eISSN">1573-7365</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Immunoglubulin (Ig)M responses directed to oxidative specific epitopes (OSEs) and nitric oxide (NO)-adducts are significantly associated with major depression and physio-somatic symptoms. End of term serum IgM responses to OSEs and NO-adducts were assayed in pregnant women with (n = 24) and without prenatal depression (n = 25) as well as in 24 non-pregnant women. Associations of IgM/IgA responses to Gram-negative gut commensal bacteria (leaky gut index) and IgA/IgM responses to tryptophan catabolites (TRYCATs) were analyzed. IgM responses to OSEs, but not NO-adducts, were significantly reduced at the end of term. There were no significant associations between IgM responses to OSEs and perinatal depression, whilst IgM responses to NO-adducts, especially NO-cysteinyl, were significantly associated with a lifetime major depression. IgM responses to OSEs and NO-cysteinyl were significantly associated with IgA/IgM responses to Gram-negative bacteria, especially Morganella morganii, Klebsiella pneumoniae and Citrobacter koseri. IgM responses to NO-adducts and OSEs, especially malondialdehyde and myristic acid, and C-reactive protein (CRP) were inversely associated with TRYCAT pathway activity, whilst a lifetime depression and Pseudomonas putida were positively associated. The attenuation of natural IgM-mediated responses to OSEs at the end of term may indicate lowered activity of this part of the compensatory (anti-)inflammatory reflex system and may be partly explained by lowered bacterial translocation. Increased IgM responses to NO-cysteinyl is a biomarker of lifetime depression and may be induced by bacterial translocation. Natural IgM-mediated autoimmune responses, increased nitrosylation and higher CRP levels may have negative regulatory effects on the TRYCAT pathway.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>France</li><li>Royaume-Uni</li><li>Thaïlande</li></country><region><li>Angleterre</li><li>Aquitaine</li><li>Aquitaine-Limousin-Poitou-Charentes</li><li>Ceará</li><li>Grand Londres</li></region><settlement><li>Bordeaux</li><li>Londres</li><li>Talence</li></settlement><orgName><li>Université fédérale du Ceará</li></orgName></list><tree><country name="Thaïlande"><noRegion><name sortKey="Roomruangwong, Chutima" sort="Roomruangwong, Chutima" uniqKey="Roomruangwong C" first="Chutima" last="Roomruangwong">Chutima Roomruangwong</name></noRegion><name sortKey="Kanchanatawan, Buranee" sort="Kanchanatawan, Buranee" uniqKey="Kanchanatawan B" first="Buranee" last="Kanchanatawan">Buranee Kanchanatawan</name><name sortKey="Maes, Michael" sort="Maes, Michael" uniqKey="Maes M" first="Michael" last="Maes">Michael Maes</name><name sortKey="Sirivichayakul, Sunee" sort="Sirivichayakul, Sunee" uniqKey="Sirivichayakul S" first="Sunee" last="Sirivichayakul">Sunee Sirivichayakul</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Anderson, George" sort="Anderson, George" uniqKey="Anderson G" first="George" last="Anderson">George Anderson</name></region></country><country name="Brésil"><region name="Ceará"><name sortKey="Carvalho, Andre F" sort="Carvalho, Andre F" uniqKey="Carvalho A" first="André F" last="Carvalho">André F. Carvalho</name></region></country><country name="France"><region name="Aquitaine-Limousin-Poitou-Charentes"><name sortKey="Duleu, Sebastien" sort="Duleu, Sebastien" uniqKey="Duleu S" first="Sebastien" last="Duleu">Sebastien Duleu</name></region><name sortKey="Geffard, Michel" sort="Geffard, Michel" uniqKey="Geffard M" first="Michel" last="Geffard">Michel Geffard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A31 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A31 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:28600633
|texte= IgM-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (TRYCAT) pathway.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28600633" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |